diff --git a/README.md b/README.md
new file mode 100644
index 0000000..9caf57e
--- /dev/null
+++ b/README.md
@@ -0,0 +1,10 @@
+## HRI codon usage
+
+This repository provides analysis for the codon usage results in the following study:
+
+
+Alvarez-Castelao, B., tom Dieck, S., Fusco, C.M., Donlin-Asp, P.G., Perez, J.D., and Schuman, E.M. (2020)
+The switch-like expression of Heme-regulated kinase 1 mediates neuronal proteostasis following proteasome inhibition.
+*eLife*, [in press](https://elifesciences.org/articles/52714).
+
+HRI uses more rare codons than the 86.78% of the genes expressed in the brain (see publication [methods](https://elifesciences.org/articles/52714) for more details).