Skip to content

To many gaps in motifs done by GLAM2 #62

Open
renewiegandt opened this issue Jan 12, 2019 · 0 comments
Open

To many gaps in motifs done by GLAM2 #62

renewiegandt opened this issue Jan 12, 2019 · 0 comments
Assignees
Labels
enhancement New feature or request

Comments

@renewiegandt
Copy link
Collaborator

With huge clusters GLAM2 has problems finding motifs without (too) many gaps.

A possible solution are the following parameters which can be set:

Tuning deletion and insertion preferences
Use -D and -E to tune deletion preferences, and use -I and -J to tune insertion preferences. The relative values of -D and -E control glam2's aversion to deletions: increasing -E relative to -D makes it more averse. Likewise, increasing -J relative to -I makes glam2 more averse to insertions. The absolute values of -D and -E control how much glam2 prefers deletions to occur at the same (fragile) positions: if -D and -E are both low, it strongly prefers deletions to occur at the same positions, otherwise not. Likewise, if -I and -J are both low, it strongly prefers insertions to occur at the same positions. To turn off deletions and insertions completely, set -E and -J to huge values:

glam2 -E 1e99 -J 1e99 n my_nucs.fa

By setting the -E and -J Parameter higher it could/should solve the problem.

@renewiegandt renewiegandt added the enhancement New feature or request label Jan 12, 2019
@renewiegandt renewiegandt self-assigned this Jan 12, 2019
@renewiegandt renewiegandt changed the title To many gaps in motifs done b GLAM2 To many gaps in motifs done by GLAM2 Jan 12, 2019
Sign in to join this conversation on GitHub.
Labels
enhancement New feature or request
Projects
None yet
Development

No branches or pull requests

1 participant