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With huge clusters GLAM2 has problems finding motifs without (too) many gaps.
A possible solution are the following parameters which can be set:
Tuning deletion and insertion preferences
Use -D and -E to tune deletion preferences, and use -I and -J to tune insertion preferences. The relative values of -D and -E control glam2's aversion to deletions: increasing -E relative to -D makes it more averse. Likewise, increasing -J relative to -I makes glam2 more averse to insertions. The absolute values of -D and -E control how much glam2 prefers deletions to occur at the same (fragile) positions: if -D and -E are both low, it strongly prefers deletions to occur at the same positions, otherwise not. Likewise, if -I and -J are both low, it strongly prefers insertions to occur at the same positions. To turn off deletions and insertions completely, set -E and -J to huge values:
glam2 -E 1e99 -J 1e99 n my_nucs.fa
By setting the -E and -J Parameter higher it could/should solve the problem.
The text was updated successfully, but these errors were encountered:
With huge clusters GLAM2 has problems finding motifs without (too) many gaps.
A possible solution are the following parameters which can be set:
Tuning deletion and insertion preferences
Use -D and -E to tune deletion preferences, and use -I and -J to tune insertion preferences. The relative values of -D and -E control glam2's aversion to deletions: increasing -E relative to -D makes it more averse. Likewise, increasing -J relative to -I makes glam2 more averse to insertions. The absolute values of -D and -E control how much glam2 prefers deletions to occur at the same (fragile) positions: if -D and -E are both low, it strongly prefers deletions to occur at the same positions, otherwise not. Likewise, if -I and -J are both low, it strongly prefers insertions to occur at the same positions. To turn off deletions and insertions completely, set -E and -J to huge values:
glam2 -E 1e99 -J 1e99 n my_nucs.fa
By setting the -E and -J Parameter higher it could/should solve the problem.
The text was updated successfully, but these errors were encountered: