diff --git a/drivers/gpu/drm/amd/display/dc/dcn10/dcn10_resource.c b/drivers/gpu/drm/amd/display/dc/dcn10/dcn10_resource.c
index 1a83b8f589d46..c2af208b81eb4 100644
--- a/drivers/gpu/drm/amd/display/dc/dcn10/dcn10_resource.c
+++ b/drivers/gpu/drm/amd/display/dc/dcn10/dcn10_resource.c
@@ -1215,6 +1215,7 @@ static enum dc_status dcn10_validate_global(struct dc *dc, struct dc_state *cont
 	bool video_large = false;
 	bool desktop_large = false;
 	bool dcc_disabled = false;
+	bool mpo_enabled = false;
 
 	for (i = 0; i < context->stream_count; i++) {
 		if (context->stream_status[i].plane_count == 0)
@@ -1223,6 +1224,9 @@ static enum dc_status dcn10_validate_global(struct dc *dc, struct dc_state *cont
 		if (context->stream_status[i].plane_count > 2)
 			return DC_FAIL_UNSUPPORTED_1;
 
+		if (context->stream_status[i].plane_count > 1)
+			mpo_enabled = true;
+
 		for (j = 0; j < context->stream_status[i].plane_count; j++) {
 			struct dc_plane_state *plane =
 				context->stream_status[i].plane_states[j];
@@ -1246,6 +1250,10 @@ static enum dc_status dcn10_validate_global(struct dc *dc, struct dc_state *cont
 		}
 	}
 
+	/* Disable MPO in multi-display configurations. */
+	if (context->stream_count > 1 && mpo_enabled)
+		return DC_FAIL_UNSUPPORTED_1;
+
 	/*
 	 * Workaround: On DCN10 there is UMC issue that causes underflow when
 	 * playing 4k video on 4k desktop with video downscaled and single channel