diff --git a/python-3.9.12-0.build.sh b/python-3.9.12-0.build.sh
new file mode 100755
index 0000000..ecba2a5
--- /dev/null
+++ b/python-3.9.12-0.build.sh
@@ -0,0 +1,689 @@
+#! /bin/bash
+
+# COOKIE=$(mcookie|cut -c-8); grep -v V_GREP_ME $0 > /dev/shm/runme-$COOKIE.sh ; sleep 0.3; exec bash /dev/shm/runme-$COOKIE.sh
+# TESTING=1
+
+PKG=python
+VERSION=3.9.12
+BUILD=0
+PYTHONVER=${VERSION%.*}
+
+CUDADIR=/pkg/cuda-11.1.1-0
+
+PREFIX=/pkg/$PKG-$VERSION-$BUILD
+if [ -n "$TESTING" ]; then PREFIX=/scratch/local2/$PKG-$VERSION-$BUILD ; fi
+
+PATH=/bin:/usr/bin:/usr/sbin:/usr/local/bin
+
+set -xe
+umask 022
+
+BUILD_TMPDIR=/scratch/local2/$PKG-$VERSION-$BUILD.$USER.build.tmp
+
+test -d $BUILD_TMPDIR && ( chmod -R u+rwx $BUILD_TMPDIR || true ; rm -rf $BUILD_TMPDIR )
+mkdir -p $BUILD_TMPDIR/home/.cache/pip
+mkdir -p $BUILD_TMPDIR/home/.local
+# copy script to an accessible location
+cp $0 $BUILD_TMPDIR; ME="$BUILD_TMPDIR/$(basename $0)"
+export TMPDIR=$BUILD_TMPDIR
+export HOME=$BUILD_TMPDIR/home
+
+exec </dev/null
+
+mkdir -p $PREFIX
+cat >$PREFIX/profile <<-EOF
+	. $CUDADIR/profile
+	PATH=$PREFIX/bin:\$PATH
+	export LD_LIBRARY_PATH=$PREFIX/lib\${LD_LIBRARY_PATH:+:}\$LD_LIBRARY_PATH
+	PKG_CONFIG_PATH=$PREFIX/lib/pkgconfig\${PKG_CONFIG_PATH:+:}\$PKG_CONFIG_PATH
+	export PKG_CONFIG_PATH
+	if [ -d $PREFIX/.compatlibs ]; then export LD_LIBRARY_PATH=$PREFIX/.compatlibs\${LD_LIBRARY_PATH:+:}\$LD_LIBRARY_PATH ; fi
+EOF
+. $PREFIX/profile
+
+NPROC=$(( $(nproc) * 4 / 5 + 1 ))
+export MAKEFLAGS="-j $NPROC"
+
+# bookkeeping, spots package downgrades
+PIPMETADIR=$PREFIX/share/pipmeta
+mkdir -p $PIPMETADIR
+
+BUILDDIR=$PREFIX/build
+
+mkdir -p $BUILDDIR
+cd $BUILDDIR
+
+# if false; then ######### DEBUG_BASE DEBUG_TF
+
+#URL=https://www.python.org/ftp/python/$VERSION/Python-$VERSION.tar.xz
+URL="https://beehive.molgen.mpg.de/4b5fda03e3fbfceca833c997d501bcca/Python-3.9.12.tar.xz"
+test -e Python-$VERSION.tar.xz || wget -nv $URL
+test -d Python-$VERSION || tar -xf Python-$VERSION.tar.xz
+cd Python-$VERSION
+
+LDFLAGS="-Wl,-rpath=$PREFIX/lib" \
+./configure \
+        --prefix=$PREFIX \
+        --enable-shared
+
+make -j $NPROC
+# make test # || true # 'test_socket' seems to run for ever
+make install
+# it might come to happen that something down the line may just call 'python', defuse ...
+test -e $PREFIX/bin/python || ln -s python3 $PREFIX/bin/python
+
+( # sip: tool to create Python bindings for C and C++ libraries., v6 is out, but not so popular at the moment
+  cd $BUILDDIR
+  SIP_VERSION=4.19.24
+
+  # orig: https://www.riverbankcomputing.com/static/Downloads/sip/$SIP_VERSION/sip-$SIP_VERSION.tar.gz
+  BEEHIVE=https://beehive.molgen.mpg.de/595e9ad6bb0a4b3a6ea92c163a05d19c/sip-4.19.24.tar.gz
+  test -e sip-$SIP_VERSION.tar.gz || wget -nv $BEEHIVE
+  test -d sip-$SIP_VERSION || tar -xf sip-$SIP_VERSION.tar.gz
+
+  cd sip-$SIP_VERSION
+
+  #### ATTN!
+  #### python meanders between /python${PYTHONVER} and /python${PYTHONVER}m
+
+  python3 configure.py \
+      -b $PREFIX/bin \
+      -d $PREFIX/lib/python$PYTHONVER/site-packages \
+      -e $PREFIX/include/python${PYTHONVER} \
+      -v $PREFIX/share/sip \
+      --sip-module=sip
+
+  # well, right here share/sip is spoilage, but maybe some packages will use the decent sip later on ...
+  mkdir -p $PREFIX/share/sip
+  make -j $NPROC
+  make install
+)
+
+
+( # now for the private (sic!) version required by newer PyQt
+  cd $BUILDDIR
+  SIP_VERSION=4.19.24
+  mkdir -p private_sip
+  cd private_sip
+
+  # orig: https://www.riverbankcomputing.com/static/Downloads/sip/$SIP_VERSION/sip-$SIP_VERSION.tar.gz
+  BEEHIVE=https://beehive.molgen.mpg.de/595e9ad6bb0a4b3a6ea92c163a05d19c/sip-4.19.24.tar.gz
+  test -e sip-$SIP_VERSION.tar.gz || wget -nv $BEEHIVE
+  test -d sip-$SIP_VERSION || tar -xf sip-$SIP_VERSION.tar.gz
+
+  cd sip-$SIP_VERSION
+
+  # note $PREFIX/share/sip/PyQt5 is mandatory
+  python3 configure.py \
+      -d $PREFIX/lib/python$PYTHONVER/site-packages \
+      -v $PREFIX/share/sip/PyQt5 \
+      --no-tools \
+      --sip-module=PyQt5.sip
+
+  mkdir -p $PREFIX/share/sip/PyQt5
+  make -j $NPROC
+  # The resulting sip.so in site-packages/PyQt5 differs indeed a bit (grep for PyQt5)
+  make install
+)
+
+(
+  cd $BUILDDIR
+  PYQT_VERSION=5.15.2
+
+  # orig: https://files.pythonhosted.org/packages/28/6c/640e3f5c734c296a7193079a86842a789edb7988dca39eab44579088a1d1/PyQt5-5.15.2.tar.gz
+  BEEHIVE=https://beehive.molgen.mpg.de/b94576e9e013210dc5aba061913e4bd4/PyQt5-5.15.2.tar.gz
+  test -e PyQt5-$PYQT_VERSION.tar.gz || wget -nv $BEEHIVE
+  test -d PyQt5-$PYQT_VERSION || tar -xf PyQt5-$PYQT_VERSION.tar.gz
+
+  cd PyQt5-$PYQT_VERSION
+
+  #### ATTN!
+  #### python meanders between /python${PYTHONVER} and /python${PYTHONVER}m
+
+  # export QTDIR=/usr/local/qt5
+  python3 configure.py \
+    -b $PREFIX/bin \
+    -d $PREFIX/lib/python$PYTHONVER/site-packages \
+    -n $PREFIX/share/qsci \
+    -q /usr/local/qt5/bin/qmake \
+    -v $PREFIX/share/sip/PyQt5 \
+    --sip-incdir=$PREFIX/include/python${PYTHONVER} \
+    --confirm-license \
+    --no-qml-plugin \
+    --no-designer-plugin \
+    --no-dist-info \
+    --verbose
+
+  make -j $NPROC
+  make install
+)
+
+(
+  cd $BUILDDIR
+  QSCINTILLA_VERSION=2.11.6
+
+  # orig: https://www.riverbankcomputing.com/static/Downloads/QScintilla/$QSCINTILLA_VERSION/QScintilla-$QSCINTILLA_VERSION.tar.gz
+  BEEHIVE=https://beehive.molgen.mpg.de/343cd0c2c8b425518df2e51eb994fbc6/QScintilla-2.11.6.tar.gz
+  test -e QScintilla-$QSCINTILLA_VERSION.tar.gz || wget -nv $BEEHIVE
+  test -d QScintilla-$QSCINTILLA_VERSION || tar -xf QScintilla-$QSCINTILLA_VERSION.tar.gz
+
+  cd QScintilla-$QSCINTILLA_VERSION
+  cd Python
+
+  # apidir follows PyQt, not Qt (default is: QT_INSTALL_DATA/qsci)
+  python3 configure.py \
+    --pyqt=PyQt5 \
+    --qmake=/usr/local/qt5/bin/qmake \
+    --apidir=$PREFIX/share/qsci \
+    --no-dist-info
+
+  make -j $NPROC
+  make install
+)
+
+# fi ######### DEBUG_BASE (1)
+# cd $BUILDDIR
+
+python3 -m ensurepip
+pip3 install --prefix=$PREFIX -I pip
+( # fix 'please update' noise from pip
+  cd $PREFIX/lib/python$PYTHONVER/site-packages
+  sed -ne '/^#Epatch:pip/ s/^#Epatch:\S* // p' $ME | patch -p1 --verbose
+)
+
+pip3 list > $PIPMETADIR/pip3list_initial
+
+# ATTN: numpy=1.21.x is out but not everybody like it already (e.g. SciPy ...)
+pip3 install --prefix=$PREFIX numpy==1.20.3
+pip3 install --prefix=$PREFIX ipython[all]
+
+# install the basic ballpark ...
+# numpy holds no ref to *_MAX_THREADS, albeit it's an issue, fix via profile?
+# still persisting: NUMEXPR_MAX_THREADS issue caused by numexpr.utils (braindead defaults from this dependency)
+pip3 install --prefix=$PREFIX SciPy Matplotlib pandas SymPy nose statsmodels
+# clean up some dirt that statsmodels placed also into $PREFIX
+rm -vf $PREFIX/LICENSE.txt
+rm -vf $PREFIX/setup.cfg
+
+pip3 install --prefix=$PREFIX Cython
+
+# libxml2-python from pypi isn't up to date, cause lxml seems to be the favored binding 
+# do this early, not that some dependency tries it. (btw. libxslt-python isn't ported to python3)
+(
+  . ${PREFIX}/profile
+  LIBXML2_VERSION=2.9.12
+  # orig: http://xmlsoft.org/sources/libxml2-${PKGVERSION}.tar.gz
+  BEEHIVE=https://beehive.molgen.mpg.de/f433a39be087a9f0b197eb2307ad9f75/libxml2-2.9.12.tar.gz
+  test -e libxml2-$LIBXML2_VERSION.tar.gz || wget -nv $BEEHIVE
+  test -d libxml2-$LIBXML2_VERSION || tar -xf libxml2-$LIBXML2_VERSION.tar.gz libxml2-$LIBXML2_VERSION/python
+  cd libxml2-$LIBXML2_VERSION/python
+  python3 setup.py build
+  python3 setup.py install
+)
+
+pip3 install --prefix=$PREFIX pysam
+pip3 install --prefix=$PREFIX seaborn
+pip3 install --prefix=$PREFIX scikit-learn
+#pip3 install --prefix=$PREFIX metaseq        # fails (Latest commit fa875d1 on Jan 10, 2017)
+pip3 install --prefix=$PREFIX Mako
+pip3 install --prefix=$PREFIX meson          # required in mariux
+
+pip3 install --prefix=$PREFIX cutadapt       # Helpdesk 01/24/18 16:19, Sabrina Krakau
+pip3 install --prefix=$PREFIX pygobject      # Helpdesk 03/26/18 14:19, Virginie Stanisla
+pip3 install --prefix=$PREFIX blink1         # Blink1-lib 07/04/18 12:00, Niclas Hofmann
+
+pip3 install --prefix=$PREFIX umi-tools
+pip3 install --prefix=$PREFIX sphinx
+pip3 install --prefix=$PREFIX recommonmark
+pip3 install --prefix=$PREFIX fastcluster
+pip3 install --prefix=$PREFIX pydot
+pip3 install --prefix=$PREFIX pygraphviz
+pip3 install --prefix=$PREFIX deeptools
+pip3 install --prefix=$PREFIX HTSeq
+pip3 install --prefix=$PREFIX keras
+pip3 install --prefix=$PREFIX keras_preprocessing # tensorflow ...
+pip3 install --prefix=$PREFIX MotifScan      # Alena 30.8.2018
+pip3 install --prefix=$PREFIX MAmotif
+pip3 install --prefix=$PREFIX hic2cool       # Helpdesk Robert Schoepflin 17.09.2018
+#pip3 install --prefix=$PREFIX hifive         # only python 2.7+
+pip3 install --prefix=$PREFIX snakemake
+pip3 install --prefix=$PREFIX virtualenv     # Donald
+pip3 install --prefix=$PREFIX odfpy          # Donald
+pip3 install --prefix=$PREFIX Dumper         # Thomas
+pip3 install --prefix=$PREFIX igraph
+pip3 install --prefix=$PREFIX louvain        # monocle3 prep for Helene
+pip3 install --prefix=$PREFIX selenium       # 19.7.19 Kreitler  -> https://webxray.org/
+pip3 install --prefix=$PREFIX cooltools      # Maria Valieva 17.7.2019
+pip3 install --prefix=$PREFIX gmpy           # From viper context (Helpdesk Laura Glaser 9.8.2019)
+pip3 install --prefix=$PREFIX torch
+pip3 install --prefix=$PREFIX torchvision
+pip3 install --prefix=$PREFIX plotly
+pip3 install --prefix=$PREFIX pyOpenCL
+pip3 install --prefix=$PREFIX docopt
+pip3 install --prefix=$PREFIX dbus-python
+pip3 install --prefix=$PREFIX distro
+pip3 install --prefix=$PREFIX ply
+pip3 install --prefix=$PREFIX threadpoolctl
+
+pip3 install --prefix=$PREFIX pyopengl
+# creates error, so remove it
+rm -rf ${PREFIX}/lib/python$PYTHONVER/site-packages/OpenGL/Tk
+
+# pip3 install --prefix=$PREFIX HiCExplorer  # Would be a nice to have, but it likes to downgrade too much, pick some cherries
+pip3 install --prefix=$PREFIX HiCMatrix
+pip3 install --prefix=$PREFIX pybedtools
+pip3 install --prefix=$PREFIX gffutils
+pip3 install --prefix=$PREFIX --no-deps "pyGenomeTracks" # example produces plots, so give it a chance, otherwise it's just a dumbfucked downgrader
+pip3 install --prefix=$PREFIX python-bioformats
+
+pip3 install --prefix=$PREFIX jupyterlab      # request Peter Arndt
+pip3 install --prefix=$PREFIX jupyterlab-git
+pip3 install --prefix=$PREFIX igv_jupyterlab  # Matthias Lienhard HD 01-04-2020
+pip3 install --prefix=$PREFIX igv-jupyter
+mkdir -vp $PREFIX/share/jupyter/lab/settings  # try to defeat a silly error in jupyter labextension install
+
+pip3 install --prefix=$PREFIX scour           # https://github.molgen.mpg.de/mariux64/pkg-scripts/issues/98
+pip3 install --prefix=$PREFIX multiqc
+
+pip3 install --prefix=$PREFIX thonny          # nice little ide, kreitler
+pip3 install --prefix=$PREFIX pybind11
+pip3 install --prefix=$PREFIX svgwrite
+pip3 install --prefix=$PREFIX pyomo
+pip3 install --prefix=$PREFIX jsbsim          # kreitler, hobby
+
+pip3 install --prefix=$PREFIX bioservices
+pip3 install --prefix=$PREFIX pairtools
+pip3 install --prefix=$PREFIX SharedArray
+pip3 install --prefix=$PREFIX pyabc           # dependency for stochkit, HD 20.07.20 Gemma Noviello
+pip3 install --prefix=$PREFIX petab
+pip3 install --prefix=$PREFIX tadtool         # HD 26.01.21 Michael Robson
+# pip3 install --prefix=$PREFIX perf          # fails, issue from Paul sep-20, no clue...
+# pip3 install --prefix=$PREFIX glpk-py       # kreitler, fails, wants setuptools_scm, do I want setuptools_scm?
+pip3 install --prefix=$PREFIX helen           # HD, a dependency from a request by helene :)
+pip3 install --prefix=$PREFIX umap            # HD, used by Matthias Lienhard
+
+pip3 install --prefix=$PREFIX macs2           # HD, Alessa Ringel, Tobias Zehnder, old python2 version broke after glibc update
+pip3 install --prefix=$PREFIX macs3
+
+pip3 install --prefix=$PREFIX biopython       # HD 2021-07-23 Magalhaes/Hnisz alphafold related (cool that we have missed biopython so far, LOL)
+pip3 install --prefix=$PREFIX dm-tree
+pip3 install --prefix=$PREFIX dm-haiku
+# pip3 install --prefix=$PREFIX jaxlib        # these should be build from source, otherwise it will have trouble finding the right cuda
+# pip3 install --prefix=$PREFIX jax
+pip3 install --prefix=$PREFIX flatbuffers
+pip3 install --prefix=$PREFIX contextlib2
+pip3 install --prefix=$PREFIX ml_collections
+
+pip3 install --prefix=$PREFIX wheel           # wheel is evil, but jaxlib needs it, and tf would pull it anyway
+
+
+# fi ######### DEBUG_BASE (2)
+# cd $BUILDDIR
+
+# jax/jaxlib
+(
+  . ${PREFIX}/profile
+  . /pkg/bazel-4.1.0-0/profile
+  cd $BUILDDIR
+
+  # orig: https://github.com/google/jax/archive/refs/tags/jaxlib-v0.1.71.tar.gz
+  BEEHIVE=https://beehive.molgen.mpg.de/10b3082f32e4088a139b8a5b9591ea9f/jax-jaxlib-v0.1.71.tar.gz
+  test -e jax-jaxlib-v0.1.71.tar.gz || wget -nv $BEEHIVE
+  test -d jax-jaxlib-v0.1.71 || tar -xf jax-jaxlib-v0.1.71.tar.gz
+
+  cd jax-jaxlib-v0.1.71
+  test -d dist && rm -f dist/*
+
+  export JAX_CUDA_VERSION=11.1 # just to give a '+cuda111' in the wheel name
+
+  python3 build/build.py \
+    --target_cpu_features native \
+    --enable_cuda \
+    --cuda_path /pkg/cuda-11.1.1-0 \
+    --cuda_version 11.1 \
+    --cudnn_path /pkg/cuda-11.1.1-0 \
+    --cudnn_version 8.0.4 \
+    --noenable_tpu
+
+  # result looks like dist/jaxlib-0.1.71-cp39-none-manylinux2010_x86_64.whl
+  pip3 install --prefix=$PREFIX ./dist/*.whl
+  # this brings the jax package
+  pip3 install --prefix=$PREFIX .
+)
+
+# boost for pycuda
+(
+  . ${PREFIX}/profile
+  BOOST_VERSION=(1.75.0 1_75_0)
+  PKGCFLAGS="-O2 -fPIC"
+
+  cd $BUILDDIR
+  # orig: https://dl.bintray.com/boostorg/release/1.75.0/source/boost_1_75_0.tar.gz
+  BEEHIVE=https://beehive.molgen.mpg.de//38813f6feb40387dfe90160debd71251/boost_1_75_0.tar.gz
+  test -e boost_${BOOST_VERSION[1]}.tar.gz || wget -nv $BEEHIVE
+  test -d boost-${BOOST_VERSION[0]} || mkdir boost-${BOOST_VERSION[0]} && tar -xf boost_${BOOST_VERSION[1]}.tar.gz -C boost-${BOOST_VERSION[0]} --strip-components=1
+
+  #### ATTN!
+  #### python meanders between /python${PYTHONVER} and /python${PYTHONVER}m
+
+  cd boost-${BOOST_VERSION[0]}
+  sed -e "/using python/ s|;|: ${PREFIX}/include/python${PYTHONVER} ;|" \
+      -i bootstrap.sh
+
+  ./bootstrap.sh \
+    --with-toolset=gcc \
+    --with-icu \
+    --with-python=$PREFIX/bin/python3 \
+    --with-libraries=python,thread || exit 1
+
+  ./b2 \
+    -j $NPROC \
+    --layout=system \
+    --build-dir=build-python3 \
+    --prefix=$PREFIX \
+    --libdir=$PREFIX/lib \
+    --build-type=minimal \
+    toolset=gcc \
+    variant=release \
+    debug-symbols=off \
+    link=shared \
+    threading=multi \
+    runtime-link=shared \
+    python=$PYTHONVER \
+    cflags="$PKGCFLAGS" \
+    cxxflags="$PKGCFLAGS" \
+    install || exit 1
+)
+
+# use pycuda git version to get GL support
+(
+  PYCUDAVERS=2020.1
+  PYTHON_LIBNAME=boost_python${PYTHONVER/./}
+
+  . ${PREFIX}/profile
+  cd $BUILDDIR
+
+  # future build might try this one
+  # https://github.com/inducer/pycuda/archive/refs/tags/v2021.1.tar.gz
+
+  # orig: https://github.com/inducer/pycuda/archive/v2020.1.tar.gz
+  BEEHIVE=https://beehive.molgen.mpg.de/580562d7af4d3249c5b42a1df8d428a0/pycuda-2020.1.tar.gz
+  test -e pycuda-${PYCUDAVERS}.tar.gz || wget -nv $BEEHIVE
+  test -d pycuda-${PYCUDAVERS} || tar -xf pycuda-${PYCUDAVERS}.tar.gz
+
+  cd pycuda-${PYCUDAVERS}
+  test -e siteconf.py && rm siteconf.py
+  python3 configure.py \
+    --cuda-enable-gl \
+    --cuda-root=$CUDADIR \
+    --no-use-shipped-boost \
+    --boost-python-libname=$PYTHON_LIBNAME \
+    --boost-inc-dir=$PREFIX/include \
+    --boost-lib-dir=$PREFIX/lib \
+    --cudadrv-lib-dir='${CUDA_ROOT}/lib,${CUDA_ROOT}/lib/stubs' \
+    --cudart-lib-dir='${CUDA_ROOT}/lib,${CUDA_ROOT}/lib/stubs' \
+    --curand-lib-dir='${CUDA_ROOT}/lib,${CUDA_ROOT}/lib/stubs' \
+    --ldflags=-L$PREFIX/lib
+
+  python3 setup.py install --prefix $PREFIX
+)
+
+(
+  # orig: https://github.com/nboley/idr/archive/2.0.3/idr-2.0.3.tar.gz # HD: Tobias Zehnder, 18.3.21
+  BEEHIVE=https://beehive.molgen.mpg.de/1bec61b526bb1dcf92a5ab99c27852d0/idr-2.0.3.tar.gz
+  test -e idr-2.0.3.tar.gz || wget -nv $BEEHIVE
+  test -d idr-2.0.3 || tar -xf idr-2.0.3.tar.gz
+  cd idr-2.0.3
+  python3 setup.py build
+  python3 setup.py install --prefix $PREFIX
+)
+
+(
+  # orig: https://github.com/stacked-git/stgit/archive/v1.0/stgit-1.0.tar.gz # Paul mariux64/pkg-scripts/issues/152
+  BEEHIVE=https://beehive.molgen.mpg.de/b20ab5a197fc3a141f4b00c5859c0a3b/stgit-1.0.tar.gz
+  test -e stgit-1.0.tar.gz || wget -nv $BEEHIVE
+  test -d stgit-1.0 || tar -xf stgit-1.0.tar.gz
+  cd stgit-1.0
+  python3 setup.py build
+  python3 setup.py install --prefix $PREFIX
+)
+
+(
+  # orig: https://github.com/openmm/openmm/archive/refs/tags/7.5.1.tar.gz
+  BEEHIVE=https://beehive.molgen.mpg.de/12fefb6ca030d1f4aace78ac1a8b94c3/openmm-7.5.1.tar.gz
+  test -e openmm-7.5.1.tar.gz || wget -nv $BEEHIVE
+  test -d openmm-7.5.1 || tar -xf openmm-7.5.1.tar.gz
+  cd openmm-7.5.1
+
+  # replace hardcoded "/usr/local/cuda/bin/nvcc" in libOpenMMCUDA.so (crying four trouble dude?)
+  # Otherwise OPENMM_CUDA_COMPILER needs to be used
+  sed -i -e "/bin\/nvcc/ s,/usr/local/cuda/bin/nvcc,/$CUDADIR/bin/nvcc," \
+    platforms/cuda/src/CudaPlatform.cpp
+
+  # apply 'DeepMind modification' to openmm, hopefully it will leave openmm usable :)
+  sed -ne '/^#Epatch:openmmtopo/ s/^#Epatch:\S* // p' $ME | patch -p1 --verbose
+
+  mkdir -p build
+  cd build
+
+  cmake \
+   -DCMAKE_INSTALL_PREFIX=$PREFIX \
+   -DCUDA_TOOLKIT_ROOT_DIR=$CUDADIR \
+   -DBUILD_TESTING=OFF \
+   ..
+
+  make -j $NPROC
+  make install
+  # make PythonInstall # this one sucks! (ignoring all locations cleanly found by cmake before...)
+
+  echo "# openmm library part done, now python-binding."
+
+  cd python
+  OPENMM_INCLUDE_PATH=$PREFIX/include OPENMM_LIB_PATH=$PREFIX/lib python3 setup.py build
+  OPENMM_INCLUDE_PATH=$PREFIX/include OPENMM_LIB_PATH=$PREFIX/lib python3 setup.py install
+
+  # place symlinks from plugins to lib, saving a LD_LIBRARY_PATH entry
+  cd $PREFIX/lib
+  for SO in plugins/*.so; do
+    ln -sv $SO
+  done
+)
+
+(
+  # orig:https://github.com/openmm/pdbfixer/archive/refs/tags/v1.7.tar.gz
+  BEEHIVE=https://beehive.molgen.mpg.de/dd383722fcf5213537656f691f4c2053/pdbfixer-1.7.tar.gz
+  test -e pdbfixer-1.7.tar.gz || wget -nv $BEEHIVE
+  test -d pdbfixer-1.7 || tar -xf pdbfixer-1.7.tar.gz
+  cd pdbfixer-1.7
+  python3 setup.py build
+  python3 setup.py install
+)
+
+(
+  # orig:https://github.com/brentp/bwa-meth/archive/refs/tags/v0.2.2.tar.gz # HD: Sven Klages 2021-09-02
+  BEEHIVE=https://beehive.molgen.mpg.de/85e77f8c2d832af13f31d5b612ab27eb/bwa-meth-0.2.2.tar.gz
+  test -e bwa-meth-0.2.2.tar.gz || wget -nv $BEEHIVE
+  test -d bwa-meth-0.2.2 || tar -xf bwa-meth-0.2.2.tar.gz
+  cd bwa-meth-0.2.2
+  python3 setup.py build
+  python3 setup.py install
+)
+
+pip3 list > $PIPMETADIR/pip3list_ballpark
+
+# fi ######### DEBUG_TF
+# cd $BUILDDIR
+
+# finaly tensorflaw
+(
+  TFVERSION=2.5.0
+  NCCLSHORTVERSION=2.7
+
+  . ${PREFIX}/profile
+  . /pkg/bazel-4.1.0-0/profile
+  cd $BUILDDIR
+
+  # https://github.com/tensorflow/tensorflow/archive/v2.5.0.tar.gz
+  BEEHIVE=https://beehive.molgen.mpg.de/b152ebdc7f72c4d32f7a9e58aa41b80d/tensorflow-2.5.0.tar.gz
+
+  test -e tensorflow-${TFVERSION}.tar.gz || wget -nv $BEEHIVE
+  test -d tensorflow-${TFVERSION} || tar -xf tensorflow-${TFVERSION}.tar.gz
+
+  cd tensorflow-${TFVERSION}
+
+  # https://bugs.archlinux.org/task/65953
+
+  #vars for config
+  export PYTHON_BIN_PATH=${PREFIX}/bin/python3
+  export USE_DEFAULT_PYTHON_LIB_PATH=1
+  export TF_NEED_JEMALLOC=1
+  export TF_NEED_KAFKA=0
+  export TF_NEED_OPENCL_SYCL=0
+  export TF_NEED_AWS=0
+  export TF_NEED_GCP=0
+  export TF_NEED_HDFS=0
+  export TF_NEED_S3=0
+  export TF_ENABLE_XLA=1
+  export TF_NEED_GDR=0
+  export TF_NEED_VERBS=0
+  export TF_NEED_OPENCL=0
+  export TF_NEED_MPI=0
+  export TF_NEED_TENSORRT=1
+  export TF_NEED_NGRAPH=0
+  export TF_NEED_IGNITE=0
+  export TF_NEED_ROCM=0
+  export TF_SET_ANDROID_WORKSPACE=0
+  export TF_DOWNLOAD_CLANG=0
+  export TF_NCCL_VERSION=${NCCLSHORTVERSION}
+  export TF_IGNORE_MAX_BAZEL_VERSION=1
+  export NCCL_INSTALL_PATH=${CUDADIR}
+  export GCC_HOST_COMPILER_PATH=/usr/bin/gcc
+  export TF_CUDA_CLANG=0
+  export CLANG_CUDA_COMPILER_PATH=/usr/bin/clang
+  export TF_CUDA_PATHS=${CUDADIR},${CUDADIR}/extras/CUPTI,${CUDADIR}/nvvm
+  export TF_CUDA_VERSION=$(${CUDADIR}/bin/nvcc --version | sed -n 's/^.*release \(.*\),.*/\1/p')
+  export TF_CUDNN_VERSION=$(sed -n 's/^#define CUDNN_MAJOR\s*\(.*\).*/\1/p' ${CUDADIR}/include/cudnn_version.h)
+  # hardware older than sm_52 is said to be unsupported, compute_86 denotes an emulation
+  export TF_CUDA_COMPUTE_CAPABILITIES=sm_52,sm_53,sm_60,sm_61,sm_62,sm_70,sm_72,sm_75,sm_80,sm_86,compute_86
+  # stay compatible with the cluster machines
+  export CC_OPT_FLAGS="-march=nehalem"
+  export TF_NEED_CUDA=1
+
+  ./configure
+
+  bazel build \
+    --cxxopt="-march=nehalem" \
+    --copt="-march=nehalem" \
+    --noshow_loading_progress \
+    --noshow_progress \
+    --color="no" \
+    //tensorflow:libtensorflow.so \
+    //tensorflow:libtensorflow_cc.so \
+    //tensorflow:install_headers \
+    //tensorflow/tools/pip_package:build_pip_package
+
+  bazel shutdown # otherwise it hogs in cwd
+
+  # create a _clean/decent_ python package from so far created debris
+  test -d tensorflow-pip && rm -r tensorflow-pip
+  mkdir tensorflow-pip
+  ./bazel-bin/tensorflow/tools/pip_package/build_pip_package --src ${BUILDDIR}/tensorflow-pip
+  cd ${BUILDDIR}
+  # ... cope with the ??? symlink-structure placed in bazels' build-TMPDIR (-h) (tell me why ?)
+  test -e tensorflow-pip.tar && rm tensorflow-pip.tar
+  tar -chf tensorflow-pip.tar tensorflow-pip
+
+  # and perform a regular install
+  test -d tensorflow-pip && rm -r tensorflow-pip
+  tar -xf tensorflow-pip.tar
+  cd ${BUILDDIR}/tensorflow-pip
+
+  # inhibit downgrading of packages installed
+  sed -ne '/^#Epatch:tfdep/ s/^#Epatch:\S* // p' $ME | patch -p2 --verbose
+
+  python3 setup.py build
+  python3 setup.py install --prefix $PREFIX
+)
+
+pip3 list > $PIPMETADIR/pip3list_after_tensorflow
+
+# tidy up a bit
+if [ -d  $PREFIX/man/man1 ]; then
+  mv -v  $PREFIX/man/man1/* $PREFIX/share/man/man1 || true
+  rm -rf $PREFIX/man
+fi
+
+
+# load all packages, see warnings and spot installation errors
+# But don't care about r2py, a further dependence into R is not wanted!
+echo "# START load test."
+python3 -c 'help("modules")' > /dev/null
+echo "# END load test."
+
+exit
+
+### PATCHES
+
+# the code to cope with '--disable-pip-version-check' is spread over the module, so
+# just quieten the enervating/misleading update reminder for at least 3 minors ...
+
+#Epatch:pip *** a/pip/_internal/self_outdated_check.py  Mon May 16 13:16:30 2022
+#Epatch:pip --- b/pip/_internal/self_outdated_check.py  Mon May 16 15:57:31 2022
+#Epatch:pip ***************
+#Epatch:pip *** 206,211 ****
+#Epatch:pip --- 206,212 ----
+#Epatch:pip       local_version_is_older = (
+#Epatch:pip           local_version < remote_version
+#Epatch:pip           and local_version.base_version != remote_version.base_version
+#Epatch:pip +         and ( local_version.release[0] < remote_version.release[0] or local_version.release[1] < remote_version.release[1] - 3 )
+#Epatch:pip       )
+#Epatch:pip       if local_version_is_older:
+#Epatch:pip           return UpgradePrompt(old=str(local_version), new=remote_version_str)
+
+# BTW: numpy is installed ...
+
+#Epatch:tfdep --- a/tensorflow-pip/setup.py.orig       2021-07-29 21:21:33.000000000 +0200
+#Epatch:tfdep +++ b/tensorflow-pip/setup.py    2021-08-05 18:14:26.011647329 +0200
+#Epatch:tfdep @@ -77,6 +77,2 @@
+#Epatch:tfdep  REQUIRED_PACKAGES = [
+#Epatch:tfdep -    # NOTE: As numpy has releases that break semver guarantees and several other
+#Epatch:tfdep -    # deps depend on numpy without an upper bound, we must install numpy before
+#Epatch:tfdep -    # everything else.
+#Epatch:tfdep -    'numpy ~= 1.19.2',
+#Epatch:tfdep      # Install other dependencies
+
+
+# This is found in the docker image preparation for AlphaFold.
+# I'm not completely happy patching existing libraries ...
+
+#Epatch:openmmtopo --- a/wrappers/python/simtk/openmm/app/topology.py.orig   2021-04-07 22:09:01.000000000 +0200
+#Epatch:openmmtopo +++ b/wrappers/python/simtk/openmm/app/topology.py        2021-08-05 16:49:10.191954117 +0200
+#Epatch:openmmtopo @@ -355,2 +355,11 @@
+#Epatch:openmmtopo              return 'SG' in names and 'HG' not in names
+#Epatch:openmmtopo +        # This function is used to prevent multiple di-sulfide bonds from being
+#Epatch:openmmtopo +        # assigned to a given atom. This is a DeepMind modification.
+#Epatch:openmmtopo +        def isDisulfideBonded(atom):
+#Epatch:openmmtopo +            for b in self._bonds:
+#Epatch:openmmtopo +                if (atom in b and b[0].name == 'SG' and
+#Epatch:openmmtopo +                    b[1].name == 'SG'):
+#Epatch:openmmtopo +                    return True
+#Epatch:openmmtopo +
+#Epatch:openmmtopo +            return False
+#Epatch:openmmtopo  
+#Epatch:openmmtopo @@ -361,2 +370,3 @@
+#Epatch:openmmtopo              pos1 = positions[sg1.index]
+#Epatch:openmmtopo +            candidate_distance, candidate_atom = 0.3*nanometers, None
+#Epatch:openmmtopo              for j in range(i):
+#Epatch:openmmtopo @@ -366,4 +376,10 @@
+#Epatch:openmmtopo                  distance = sqrt(delta[0]*delta[0] + delta[1]*delta[1] + delta[2]*delta[2])
+#Epatch:openmmtopo -                if distance < 0.3*nanometers:
+#Epatch:openmmtopo -                    self.addBond(sg1, sg2)
+#Epatch:openmmtopo +                if distance < candidate_distance and not isDisulfideBonded(sg2):
+#Epatch:openmmtopo +                    candidate_distance = distance
+#Epatch:openmmtopo +                    candidate_atom = sg2
+#Epatch:openmmtopo +            # Assign bond to closest pair.
+#Epatch:openmmtopo +            if candidate_atom:
+#Epatch:openmmtopo +                self.addBond(sg1, candidate_atom)
+#Epatch:openmmtopo +
+#Epatch:openmmtopo +
+