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@@ -30,7 +30,7 @@ The workflow contains a variety of steps, including quality control, CpG filteri
**Quality Control**
-The workflow will find and remove low quality or unreliable samples from the data. The pipeline does this by calculating detection p-values (detP), which indicate the quality. ***minifi***, the R package used in this pipeline, creates the detP values by comparing the total signal of unmethylated and methuylated (M+U) for each CpG to a background signal level, approximated from negative control probes. A small p-value indicates reliable signal while large p-values indicate poor quality signals. We also provide the minfi qcreport, which generates other quality control plots. Poor samples are then excluded from further processing and analysis by using a detP cutoff value set by the user.
+The workflow will find and remove low quality or unreliable samples from the data. The pipeline does this by calculating detection p-values (detP), which indicate the quality. ***minfi***, the R package used in this pipeline, creates the detP values by comparing the total signal of unmethylated and methuylated (M+U) for each CpG to a background signal level, approximated from negative control probes. A small p-value indicates reliable signal while large p-values indicate poor quality signals. We also provide the minfi qcreport, which generates other quality control plots. Poor samples are then excluded from further processing and analysis by using a detP cutoff value set by the user.
**Calculating M and beta values**