diff --git a/docs/tutorials/003_gene_families_trees.md b/docs/tutorials/003_gene_families_trees.md index bac5ab7..fa54c08 100644 --- a/docs/tutorials/003_gene_families_trees.md +++ b/docs/tutorials/003_gene_families_trees.md @@ -1,6 +1,26 @@ # Tutorial: Gene families and Phylogenetic Trees +Homologous genes (genes derived from a common ancestor) are usually group into gene families. Orthologs, genes derived +from a common ancestor through speciation, are similarly grouped into OrthoGroups. CoNekT supports +[tribeMCL](https://www.ncbi.nlm.nih.gov/pubmed/11917018) and [OrthoFinder](https://github.com/davidemms/OrthoFinder) for +Homologous groups and OrthoGroups respectively. + ## Gene Families -## Phylogenetic Trees \ No newline at end of file + + +## Phylogenetic Trees + +Phylogenetic Trees generated by [OrthoFinder](https://github.com/davidemms/OrthoFinder) can be imported into CoNekT. These +can be accessed from gene pages for sequences included in the tree or the corresponding gene family page. + +A unique feature of CoNekT is that conditions can be manually curated per species and expression levels of genes in +comparable tissues/organs can be added to the phylogenetic tree. This allows for changes in expression patterns between +duplicated genes or after speciation events to be visualized. + +![phylogenetic tree](images/phylo_tree_example.png "Phylogenetic tree example") + +In the example above various genes related with cellulose synthase (an important component of plant cell walls) is shown. +Here it is immediately clear that some groups of cellulose syntases are specific for leaves while others play a role in +reproductive structure. \ No newline at end of file diff --git a/docs/tutorials/images/phylo_tree_example.png b/docs/tutorials/images/phylo_tree_example.png new file mode 100644 index 0000000..3a0e6ea Binary files /dev/null and b/docs/tutorials/images/phylo_tree_example.png differ