diff --git a/README.md b/README.md index d2a6445..94a00da 100644 --- a/README.md +++ b/README.md @@ -2,8 +2,10 @@ R Package for the Analysis of Multimodal Genes -## Description -mmRmeta is a framework to analyze multi-omics data such as RNA-seq and DNA methylation data with the focus on bimodal genes. -The workflow of mmRmeta consists of three major steps (outlined in Figure 2). First, the data needs to be acquired and preprocessed. -This is followed by the identification of bimodally expressed genes. The package mmRmeta uses mclust for model-based clustering to obtain parameter estimates and the cluster assignment of the samples. +## Description +mmRmeta is a framework to analyze multi-omics data such as RNA-seq and DNA methylation data with the focus on bimodal genes. +The workflow of mmRmeta consists of three major steps (outlined in Figure 2). First, the data needs to be acquired and preprocessed. +This is followed by the identification of bimodally expressed genes. The package mmRmeta uses mclust for model-based clustering to obtain parameter estimates and the cluster assignment of the samples. The third step is the multi-omics analysis to find relations between bimodally expressed genes and the phenotypes of the patient population via modeling regularized logistic regressions and conducting survival analyses with Cox proportional hazard models. + +![Overview](/vignettes/overview.svg)