From 24527346660504d9a8eb91baecb8e8d54bb797ca Mon Sep 17 00:00:00 2001 From: sebastianlieske Date: Tue, 11 Aug 2020 09:26:34 +0200 Subject: [PATCH] Create README.md --- README.md | 9 +++++++++ 1 file changed, 9 insertions(+) create mode 100644 README.md diff --git a/README.md b/README.md new file mode 100644 index 0000000..d2a6445 --- /dev/null +++ b/README.md @@ -0,0 +1,9 @@ +# mmRmeta +R Package for the Analysis of Multimodal Genes + + +## Description +mmRmeta is a framework to analyze multi-omics data such as RNA-seq and DNA methylation data with the focus on bimodal genes. +The workflow of mmRmeta consists of three major steps (outlined in Figure 2). First, the data needs to be acquired and preprocessed. +This is followed by the identification of bimodally expressed genes. The package mmRmeta uses mclust for model-based clustering to obtain parameter estimates and the cluster assignment of the samples. +The third step is the multi-omics analysis to find relations between bimodally expressed genes and the phenotypes of the patient population via modeling regularized logistic regressions and conducting survival analyses with Cox proportional hazard models.