ADMIRE is a semi-automatic analysis pipeline and visualization tool for Infinium HumanMethylation450K and Infinium MethylationEpic assays.
Use ADMIRE online: bioinformatics.mpi-bn.mpg.de
DNA methylation at cytosine nucleotides constitutes epigenetic gene regulation impacting cellular development and the stage of a disease. Besides whole genome bisulfit sequencing, Illumina HumanMethylation450K Assays represent a versatile and cost-effective tool to investigate changes of methylation patterns at CpG sites. ADMIRE was developed as an open source, semi-automatic analysis pipeline and visualization tool for Illumina HumanMethylation450K Assays.
- Automatic filtering and normalization
- Statistical testing and multiple testing correction
- Supports arbitrary number of samples and sample groups
- Differential methylation analysis on pre-calculated and individual genomic regions
- Provides ready-to-plug-in files for genome browsers (like IGV)
- Provides publication-ready figures for the most differentially methylated regions
- Performs gene set enrichment analysis on predefined and individual gene sets
Please cite the paper describing ADMIRE when using the web service or command line version in your research:
Preussner J, Bayer J, Kuenne C and Looso M. ADMIRE: Analysis and visualization of differential methylation in genomic regions using the Infinium HumanMethylation450 Assay. Epigenetics & Chromatin (2015).
- Issue Tracker: https://github.molgen.mpg.de/loosolab/admire/issues
- Source Code: https://github.molgen.mpg.de/loosolab/admire
If you are having issues, please feel free to send an e-mail to Jens Preußner (jens.preussner@mpi-bn.mpg.de).
The project is licensed under the MIT license.