LimiTT: Link miRNAs To Targets

LimiTT is a web-based pipeline connecting miRNA datasets and transcriptomes/proteomes via multiple experimentally validated miRNA target interaction (MTI) databases.

Introduction

LimiTT automatically links validated MTIs and affected proteins to a list of miRNAs and a list of genes or proteins mapped onto UniProt accessions (annotation file), by using the information of different databases containing experimentally verified MTIs. If no miRNAs are existent, the pipeline will predict miRNAs by the use of the given genes/proteins. With a list of UniProt accessions and their ranking values (e.g. expression profile), LimiTT will identify the significantly enriched MTI sets from the identified MTIs.

Features

• Comparison of the four MTI databases by adjusting the filtering parameters provided by LimiTT
• Identification of MTIs for a supplied miRNA list
• Identification of MTIs for a supplied target list
• Identification of MTIs for a supplied target list and filtered for a supplied miRNA list
• Enrichment analyses of identified MTI sets for a ranked target list

Documentation

We have an extensive documentation with examples available here