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type fixes README
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NatanYusupov committed Oct 12, 2023
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Expand Up @@ -30,7 +30,7 @@ The workflow contains a variety of steps, including quality control, CpG filteri

**Quality Control**
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The workflow will find and remove low quality or unreliable samples from the data. The pipeline does this by calculating detection p-values (detP), which indicate the quality. ***minifi***, the R package used in this pipeline, creates the detP values by comparing the total signal of unmethylated and methuylated (M+U) for each CpG to a background signal level, approximated from negative control probes. A small p-value indicates reliable signal while large p-values indicate poor quality signals. We also provide the minfi qcreport, which generates other quality control plots. Poor samples are then excluded from further processing and analysis by using a detP cutoff value set by the user.
The workflow will find and remove low quality or unreliable samples from the data. The pipeline does this by calculating detection p-values (detP), which indicate the quality. ***minfi***, the R package used in this pipeline, creates the detP values by comparing the total signal of unmethylated and methuylated (M+U) for each CpG to a background signal level, approximated from negative control probes. A small p-value indicates reliable signal while large p-values indicate poor quality signals. We also provide the minfi qcreport, which generates other quality control plots. Poor samples are then excluded from further processing and analysis by using a detP cutoff value set by the user.
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**Calculating M and beta values**
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