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Improve compare gene modules function. #256

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mutwil opened this issue Sep 28, 2017 · 5 comments
Open

Improve compare gene modules function. #256

mutwil opened this issue Sep 28, 2017 · 5 comments

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@mutwil
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mutwil commented Sep 28, 2017

Did you not have some prototype running already, and if yes, when will you make this available for testing?

@proost
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proost commented Sep 28, 2017

Similar clusters can be detected and graphs plotted side by side. Linking homologs with edges.
The next step would be to include phylostrata information to edges connecting homologs.

Furthermore Expression Context Conservation can be computed between homologs, however this performed quite poorly with the hrr <30 networks. I'll have to check between two hrr <100 networks to see if this becomes usable at this network density (in the original publication pcc > 0.4 was used). This would connect neighborhoods

We need more people testing to see how much priority we give these advanced features. So far the most feedback is on the heatmap, profiles, expression specificity not on anything directly related with the co-expression.

@mutwil
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mutwil commented Sep 29, 2017

Yeah, lets go with hrr<100, first neighbours for all networks. To minimize confusion fir the users, lets remove the hrr<30 instances.

@mutwil
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mutwil commented Oct 27, 2017

So the modules could be shown like this:
image

Where nodes represent gene families or label co-occurrences (the user can select which).

Phylogenetic info between the genes could be shown with the colored edges between modules:
image

@proost
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proost commented Oct 27, 2017

the second I have (with the exception of some tweaks), but there is no UI to get to a meaningful comparison yet.

@proost
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proost commented Nov 30, 2017

cytoscape-lowres

First step. The interface to get to this point is however more difficult !

Repository owner deleted a comment from mutwil Jan 25, 2018
@proost proost changed the title Compare gene modules function. Improve compare gene modules function. Jan 25, 2018
@proost proost added this to the CoNekT 2.0 milestone Jan 25, 2018
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