Analyzing chromatin accessibility in single cells is critical to better understand cellular compositions in developing, in adult and pathological tissues. Recent technical advances have scaled ATAC-seq down to the single cell level. This allows insights into dynamics of differentiation, cellular responses and epigenetics changes.
Challenges
- SC ATAC: learn on chromatin accessibility
- Validate data
- Compare results from different samples and conditions
- Expensive and difficult procedure in the wet-lab
Visualized outline
