EPIC Arrays

EPIC Arrays

DNA methylation plays an important and dynamic role in regulating gene expression. As a cheap and fast alternative to costly genome-wide interrogation of methlyation status, MethylationEPIC arrays are targeted to relevant features of the genome, e.g. genes, CpG islands and enhancer regions, and allow epigenome wide association studies in high-throughput.

Challenges

  • Quality assessment and normalization
  • Handle replicates and multiple groups
  • Vizualisation of results
  • HIgh computational load