DNA methylation plays an important and dynamic role in regulating gene expression. As a cheap and fast alternative to costly genome-wide interrogation of methlyation status, MethylationEPIC arrays are targeted to relevant features of the genome, e.g. genes, CpG islands and enhancer regions, and allow epigenome wide association studies in high-throughput.
Challenges
- Quality assessment and normalization
- Handle replicates and multiple groups
- Vizualisation of results
- HIgh computational load