Analysis and visualization of differential methylation in genomic regions

ADMIRE

DNA methylation at cytosine nucleotides constitutes epigenetic gene regulation impacting cellular development and the stage of a disease. Besides whole genome bisulfit sequencing, Illumina HumanMethylationEPIC Assays represent a versatile and cost-effective tool to investigate changes of methylation patterns at CpG sites. ADMIRE is a semi-automatic analysis pipeline and visualization tool for Infinium HumanMethylation450K and Infinium MethylationEpic assays.

Features

  • Automatic filtering and normalization
  • Statistical testing and multiple testing correction
  • Supports arbitrary number of samples and sample groups
  • Differential methylation analysis on pre-calculated and individual genomic regions
  • Provides ready-to-plug-in files for genome browsers (like IGV)
  • Provides publication-ready figures for the most differentially methylated regions
  • Performs gene set enrichment analysis on predefined and individual gene sets